Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population

Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population

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Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors.Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors.A 32-nucleotide deletion glitter foam vellen action (delta32) within the beta-chemokine receptor 5 gene (CCR5) has been described in subjects who remain uninfected despite extensive exposition to HIV-1.

The heterozygous genotype delays disease progression.This allele is common among Caucasians, but has not been found in people of African or Asian ancestry.A more common transition involving a valine to isoleucine switch in transmembrane domain I of CCR2B (64I), with unknown functional consequences, was found to delay disease progression but dorisvale station for sale not to reduce infection risk.

As the Brazilian population consists of a mixture of several ethnic groups, we decided to examine the genotype frequency of these polymorphisms in this country.There were 11.5% CCR5 heterozygotes among the HIV-1 infected population and 12.

5% among uninfected individuals, similar to data from North America and Western Europe.The prevalence of CCR2-64I homozygotes and heterozygotes was 0.06 and 15.

2%, respectively, also similar to what is known for North America and Western Europe.